On the date of October 4, 1624, Bartolomeo Imperiali, from Genoa, wrote to Galileo on this subject: "… A physician here in Genoa, called Riccardo, very learned in all sciences, the brother of Dominichino, says that with this occhialino we will know for sure the site of a certain tiny particle of the heart, which it has never been possible to see with simple vision, and which will show itself to be a thing of great consequence for medicine."

Visible in this microphotograph, taken with Galilean microscope no. 3429 of the Institute and Museum of the History of Science, Florence, are the changes in the myocardium according to Allodi.