Founded around the second half of the 19th century, the Farmacia Nera owes its name, ("black" in Italian) to the distinctive color of the entrance and the furniture, the latter decorated with gold trimming. At some time in the 1930s, the black furnishings were repainted in a wood colour, and in 1960 the entrance too was remodelled.

The pharmaceutical equipment, consisting of glass and ceramic jars, precision scales and other instruments, was adapted to and utilised in the laboratory work carried out by Dr. Giorgi from 1946 to the recent past. Up to the 1930s, candles were an important sales item, thanks to the location of the Prato Misericordia nearby.