Begun in 1846 and completed in 1855, the Hospital of San Marcello Pistoiese, which originally had only 12 beds, was built, thanks to a legacy bequeathed in 1807 by Lorenzo Pacini, to treat sick persons in the Pistoia mountain area. The hospital – observed the historian Luigi Bargiacchi in 1883 – "is furnished with all of the necessary comforts, and accepts patients having the requisites desired by the Devout Founder, and accommodation is offered free of charge, but only insofar as its forces and its income allow. Patients from the People of Mammiano have priority over the others considered." The institution was badly needed since it was located in an area that, with its iron-working industries, was one of the Grand Duchy’s important production zones.

The hospital, still active within the sphere of the Pistoia health department ASL 3, conserves its 19th century facade.