Founded in 1713 as the Mantellassi Pharmacy, it still occupies its original site. In 1820, it was taken over by the Bottari family. Destroyed during World War II, it was rebuilt after 1945. Of its antique furnishings, which, according to the testimony of Pedrazzini in 1934, must have been "rich and majestic", there remains today, over the entrance door, only a painting on wood portraying Saint Ranieri. On the inside is another painting, accomplished "by Dr. Carlo Marko", it too portraying Saint Ranieri, probably to be associated with the more ancient origins of the pharmacy when it was still called "At the Sign of San Ranieri". Of its antique pharmaceutical apparatus it still possesses a set of white ceramic jars with lids from the Sevres manufactory, dating from 1713.